PIT1 Negative Pressure Wound Therapy for Pressure Ulcer: Effect on Outcomes and Utilization Using Real-World DATA

Clinical trials evaluating negative pressure wound therapy (NPWT) as a treatment for ulcer (PU) have been inconclusive. The objective of this research was to evaluate the effect NPWT on length stay (LOS), charges, and mortality PU patients. data collected over 4-year period from large medical institution in OMNY Health System Database were used identify adult Patients excluded if also diagnosed with diabetic, chronic skin non-pressure, or varicose ulcers. Current Procedural Terminology codes divide patients into comparison cohorts. Crude estimates (percent 95% confidence interval [95% CI]) LOS charges (median, quartiles 1 3 [Q1, Q3]) generated each outcome. Propensity score methods account underlying differences between After exclusions, 749 divided (N=135) (N=614) slightly greater cohort (28.9%; CI: 21.2%-36.5%) than (22.2%; 18.9%-25.4%). incurred notably higher (median [Q1-Q3]: $65,197 [$32,232-$143,607] vs. $13,850 [$3,056-$35,929]) 11 days [7, 22] 5 [3, 9]) application propensity methods, adjusted relative risk 1.20 (95% 0.88-1.65), median 5.8 (Q1-Q3: 3.9-9.2) $30,900 $15,434-$58,868), respectively. No notable positive effects outcomes hospitalizations observed even after adjusting differences. Residual confounding by indication could be possible explanation associations outcomes. Further is needed examine longer term such readmission rates drivers cost difference.